Physical chemistry of macromolecules is a course that is frequently offered in the biochemistry curriculum of a college or university. Occasionally, it is also offered in the chemistry curriculum. When it is offered in the biochemistry curriculum, the subject matter is usually limited to biological topics and is identical to biophysical chemistry. When it is offered in the chemistry curriculum, the subject matter is often centered around synthetic polymers and the course is identical to physical polymer chemistry. Since the two disciplines are so closely related, students almost universally feel that something is missing when they take only biophysical chemistry or only physical polymer chemistry. This book emerges.