White and brown adipocytes are usually located in distinct depots; however, in response to cold, brown adipocytes appear in white fat. This response is mediated by b-adrenoceptors but there is a controversy about the sub-type(s) involved. In the present study, we exposed to cold b3 -adrenoceptor knockout mice (b3KO) on a C57BL/6J geneticbackgroundandmeasured inwhiteadipose tissue the density of multilocular cells and the expression of the brown adipocyte marker uncoupling protein-1 (UCP1).
