The dilemma every regional leadership team must resolve is how to select those investments projects most likely to spur growth in areas that will produce the desired outcomes for the region in the long-term. This is no small feat, since the leadership team must weigh the likely returns with associated risks, as well as questions of equity (“Are we investing to benefit the entire region or just a part of it?”). The Guidelines for Regional Investment Decisions help a region prioritize investments through guided, focused discussions within the leadership team. The Regional Investment Portfolio Tool represents the most advanced tool.