We have recently identified an Ets element controlling over 90%of the basal expression of the human presenilin 1 (PS1) gene. We have also shown that Ets1 and Ets2 act as trans-activators of the PS1 gene by cotransfection experiments in SK-N-SH neuronal cells. The PS1 gene is widely but dif-ferentially expressed across tissues and the expression in brain appears to be restricted to neurons. To gain further insight into the regulation of the gene we have examined the regulation of PS1 by 12-O-tetradecanoylphorbol 13-acetate (TPA). .
