Two novel toxins, Lqh6 andLqh7, isolated from the venom of the scorpionLeiurus quinquestriatus hebraeus,have in their sequence amolecular signature (8Q/KPE10) associated with a recently defined group ofa-toxins that target Na channels, namely thea-like toxins [reviewed inGordon, D., Savarin, P.,Gurevitz,M.&Zinn-Justin, S. (1998)J. Toxicol. Toxin , 131–159]. Lqh6 and Lqh7 are highly toxic to insects and mice, and inhibit the binding of a-toxins to cockroach neuronal membranes.
