The effects of pressure on structure and activity of recom-binant human acetylcholinesterase (rHuAChE) were inves-tigatedup toapressureof 300 MPausinggel electrophoresis under elevated hydrostatic pressure, fluorescence of bound 8-anilinonaphthalene-1-sulfonate (ANS) and activity meas-urements followingexposure tohighpressure.