A number of findings have suggested the involvement of protein phosphorylation in the regulation of the epithelial Na + channel (ENaC).Arecent studyhas demonstrated that the C tails of thebandcsubunits of ENaC are subject to phosphorylation by at least three protein kinases [Shi, H., Asher, C., Chigaev, A., Yung, Y., Reuveny, E., Seger, R. & Garty, H. (2002)J. Biol. , 13539–13547]. One of them was identified as ERK which phosphorylates bT613 andcT623 and affects the channel interaction with Nedd4
