The studies confirmed the glucose-lowering benefits of metformin in combination with all other available glucose-lowering medications. The widespread use of the previous recommendations in regard of levels of serum creatinine for reduction and discontinuing therapy was acknowledged. The complete substitution of estimated glomerular filtration rate (eGFR) for serum creatinine is not possible because of uncertainty surrounding methods of eGFR calculation in many people with Type 2 diabetes. An evidence call on the use of extended-release metformin preparations did not find that their use in unselected patients reduced GI side effects. Differences in cost, and lack of other documented benefit, led to the conclusion that these therapies should be.
