Natively unfolded or intrinsically unstructured proteins constitute a unique group of the protein kingdom. The evolutionary persistence of such proteins represents strong evidence in the favor of their importance and raises intriguing questions about the role of protein disorders in biological processes. Additionally, natively unfolded pro-teins,withtheir lackoforderedstructure, represent attractive targets for the biophysical studies of the unfolded polypep-tidechainunderphysiological conditionsinvitro
