Health care and hygiene programmes can help in control. Watering at night or at midday reduces the risk of being bitten by flies. Preventive measures before the onset of the disease (Chemoprophylaxis) and curative measures after the disease is clinically evident (Chemotherapy) have shown varying success in controlling and combating the disease (Table 32). As for all trypanosome diseases, drug resistance due to misuse and especially by using too small doses or diluting the drug with water or some other liquid is an increasing problem. In addition, some drugs that are effective in other domestic livestock are poorly tolerated.