Biozentrum-Pharmazie, Universitat Halle, Halle/Saale, Germany; 2Lehrstuhl fur Organische Chemie und Biochemie, Technische ¨ ¨ ¨ ¨ ¨ Universitat Munchen, Garching, Germany; 3Laboratorium fur Organische Chemie, Eidgenossische Technische Hochschule Honggerberg, ¨ Zurich, Switzerland 2C-Methyl-D -erythritol 2,4-cyclodiphosphate was recently shown to be formed from 2C-methyl-D -erythritol 4-phosphate by the consecutive action of IspD, IspE, and IspF proteins in the nonmevalonate pathway of terpenoid biosynthesis. .
