Biotherapeutics have become the main drivers for the pipeline of the pharmaceutical industry, and carry hope for millions of patients for a better life with, or even cure from, diseases for which there are no existing effective treatments. This group of medicines includes, but is not limited to, protein and nucleic acid-based therapeutics as well as different classes of vaccines and gene therapy treatments. Today, there are a few hundred licensed biotherapeutics produced from genetically engineered cells and over a thousand are in pre-clinical and clinical studies | Second Edition INCLUDES CD-ROM Handbook of Process Chromatography Development Manufacturing Validation and Economics Lars Hagel Gunter Jagschies and Gail Sofer Handbook of Process Chromatography Development Manufacturing Validation and Economics Second Edition This page intentionally left .