So begins our journey. It is a journey that others have taken before us; in fact, in reaching our destination we will rely on the efforts of those who came before. Just as Columbus retraced steps taken by others before him (perhaps as long as two millennia before he sailed), so we gratefully acknowledge the work of those who went before. Yet, like the voyage of Columbus, there is a sense of beginning, a tenor to the enterprise that makes it a voyage of discovery.