2’,3’-Dideoxynucleosides (ddNs) are the most important class of compounds active against HIV/AIDS. They act as DNA chain terminators and competitive inhibitors of viral reverse transcriptase (RT). Currently, stavudine (d4T, Zerit) is one six drugs belonging to the ddNs family that are approved by the FDA. This article describes the synthesis of generic stavudine drug from thymidine in three steps. By mean of this synthesis, stavudine was obtained in a good yield. The structure of product and intermediate were established by NMR spectroscopies.
