Safrol is a natural product, and presents especially in Sassafras oil with 80% abundance. Sassafras oil has been used for long time for treatment of some diseases such as influenza, trouble digestion, stomach and arthritis [1]. Otherwise, Sassafras oil was also used in food and cosmetic industries. Some derivatives of safrol such as heliotropin is a precious perfume used widely in cosmetic industry. Heliotropin was prepared by oxidation of isosafrol [2, 3].