One of the more promising processes for the energetic transformation of waste is the anaerobic digestion of the Organic Fraction of Municipal Solid Waste. An experimental campaign was carried out on three different samples of OFMSW from Waste Separation, one as received and two obtained after mechanical treatment: OFMSW slurry (liquid fraction) and OFMSW Waste. Anaerobic Biogasification Potential and anaerobic digestion tests were carried out, investigating the effects of inoculum and pH. The OFMSW Waste was also examined to evaluate the possibility to dispose of it in a landfill.