In this chapter, students will be able to: Know the reactions/enzymes/intermediates/co-substrates/co-factor/structures involved in the synthesis of IPP from the mevalonate pathway; know how HMG-CoA reductase is regulated, know the similarities and differences between IPP synthesis and ketone body synthesis, know the similarities and differences between IPP synthesis and ketone body synthesis. | Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids Eicosanoids Eicosanoid Synthesis cyclooxygenase Glycerolipid Biosynthesis Mevalonate kinase Phosphomevalonate kinase pyrohosphomevalonate decarboxylase Formation of the isopentenyl pyrophosphate (IPP) Two Fates of HMG-CoA Condensation of IPP into Polyprenyl Compounds Dimethylallyl pryophosphate IPP isomerase IPP Isomerase prenyltransferase prenyltransferase Squalene synthase Cholesterol Synthesis from IPP Squalene monooxygenase 2,3-oxidosqualene lanosterol cyclase cholesterol 20 steps | Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids Eicosanoids Eicosanoid Synthesis cyclooxygenase Glycerolipid Biosynthesis Mevalonate kinase Phosphomevalonate kinase pyrohosphomevalonate decarboxylase Formation of the isopentenyl pyrophosphate (IPP) Two Fates of HMG-CoA Condensation of IPP into Polyprenyl Compounds Dimethylallyl pryophosphate IPP isomerase IPP Isomerase prenyltransferase prenyltransferase Squalene synthase Cholesterol Synthesis from IPP Squalene monooxygenase 2,3-oxidosqualene lanosterol cyclase cholesterol 20 . | Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids Eicosanoids Eicosanoid Synthesis cyclooxygenase Glycerolipid Biosynthesis Mevalonate kinase Phosphomevalonate kinase pyrohosphomevalonate decarboxylase Formation of the isopentenyl pyrophosphate (IPP) Two Fates of HMG-CoA Condensation of IPP into Polyprenyl Compounds Dimethylallyl pryophosphate IPP isomerase IPP Isomerase prenyltransferase prenyltransferase Squalene synthase Cholesterol Synthesis from IPP Squalene monooxygenase 2,3-oxidosqualene lanosterol cyclase cholesterol 20 steps | Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids Eicosanoids Eicosanoid Synthesis cyclooxygenase Glycerolipid Biosynthesis Mevalonate kinase Phosphomevalonate kinase pyrohosphomevalonate decarboxylase Formation of the isopentenyl pyrophosphate (IPP) Two Fates of HMG-CoA Condensation of IPP into Polyprenyl Compounds Dimethylallyl pryophosphate IPP isomerase IPP Isomerase prenyltransferase prenyltransferase Squalene synthase Cholesterol Synthesis from IPP Squalene monooxygenase 2,3-oxidosqualene lanosterol cyclase cholesterol 20 . | Chapter 16 (Part 4) Synthesis of Eicosanoids, Glycerolipids and Isoprenoids Eicosanoids Eicosanoid Synthesis cyclooxygenase Glycerolipid Biosynthesis Mevalonate kinase Phosphomevalonate kinase pyrohosphomevalonate decarboxylase Formation of the isopentenyl pyrophosphate (IPP) Two Fates of HMG-CoA Condensation of IPP into Polyprenyl Compounds Dimethylallyl pryophosphate IPP isomerase IPP Isomerase prenyltransferase prenyltransferase Squalene synthase Cholesterol Synthesis from IPP Squalene monooxygenase 2,3-oxidosqualene lanosterol cyclase cholesterol 20 steps
