Chapter 17 - Somatic mutation and the genetics of cancer. The genetics of cancer are clearly more complex than most of the other diseases. In this chapter, we attempt to answer some basic questions about this topic that hopefully will help put the chapters on cancer in perspective and explain their organization. | PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition How Genes Are Regulated PART V Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 17 Somatic Mutation and the Genetics of Cancer Overview: Initiation of Division Cancer: A Failure of Control over Cell Division The Normal Control of Cell Division CHAPTER OUTLINE CHAPTER The relative percentages of new cancers in the United States that occur at different sites Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 17 Fig. Two unifying themes about cancer genetics Cancer is a disease of genes Multiple cancer phenotypes arise from mutations in genes that regulate cell growth and division Environmental chemicals increase mutation rates and increase chances of cancer Cancer has a different inheritance pattern than other genetic disorders Inherited mutations can predispose to cancer, but the mutations causing cancer occur in somatic cells Mutations accumulate in clonal descendants of a single cell Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 17 Overview of the initiation of cell division Two basic types of signals that tell cells whether to divide, metabolize, or die Extracellular signals – act over long or short distances Collectively known as hormones Steroids, peptides, or proteins Cell-bound signals – require direct contact between cells Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 17 An example of . | PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition How Genes Are Regulated PART V Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 17 Somatic Mutation and the Genetics of Cancer Overview: Initiation of Division Cancer: A Failure of Control over Cell Division The Normal Control of Cell Division CHAPTER OUTLINE CHAPTER The relative percentages of new cancers in the United States that occur at different sites Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 17 Fig. Two unifying themes about cancer genetics Cancer is a disease of
