Chapter 21 - Systems biology and the future of medicine. In this chapter, the following content will be discussed: What is systems biology? Biology as an informational science, the practice of systems biology, a systems approach to disease. | PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition Beyond the Individual Gene and Genome PART VI Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 21 Systems Biology and the Future of Medicine What Is Systems Biology? Biology as an Informational Science The Practice of Systems Biology A Systems Approach to Disease CHAPTER OUTLINE CHAPTER What is systems biology? Biological system – collection of interacting elements that carry out a specific biological task Can be interacting molecules; . proteins, mRNAs, metabolites, or control elements of genes Can be interacting cells; . immune system cells, hormonal network cells, or neuronal network cells Systems biology – seeks to describe and analyze the complex interactions of components within the system and in relation to components of other systems Requires a cross-disciplinary approach – teams of biologists, computer scientists, chemists, engineers, mathematicians, and physicists Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 21 Four questions to guide thinking about biological systems What are the elements of the system? Use data sets generated by genomic and proteomic tools What physical associations occur between the elements? . Protein-protein, protein-DNA, cell-cell, etc. What happens when the system is perturbed? Genetic or environmental perturbations What gives rise to a system's emergent properties? Can sometimes be greater than the sum of individual components Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or . | PowerPoint to accompany Genetics: From Genes to Genomes Fourth Edition Leland H. Hartwell, Leroy Hood, Michael L. Goldberg, Ann E. Reynolds, and Lee M. Silver Prepared by Mary A. Bedell University of Georgia Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition Beyond the Individual Gene and Genome PART VI Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display Hartwell et al., 4th edition, Chapter 21 Systems Biology and the Future of Medicine What Is Systems Biology? Biology as an Informational Science The Practice of Systems Biology A Systems Approach to Disease CHAPTER OUTLINE CHAPTER What is systems biology? Biological system – collection of interacting elements that carry out a specific biological task Can be interacting molecules; . proteins, mRNAs, metabolites, or control elements of genes Can be interacting cells; . immune system cells, .
