Lecture Microbiology - Chapter 13: Antimicrobial therapy. This chapter presents the following content: Chemotherapy, antimicrobial drug properties, drug target sites, kinds of drug side effects, drug resistance, mechanisms of resistance, novel enzyme activity,. | ANTIMICROBIAL THERAPY CHAPTER 13 Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. Chemotherapy Antibiotics Synthetics Semi-synthetics Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. History Ancient remedies – Molds in Egyptian times – Quinine Ehrlich – Salvarsan Domagk – Dyes led to discovery of sulfa drugs Fleming – Penicillium mold Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. Antimicrobial Drug Properties Selective Toxicity Activity Spectrum – Broad vs. Narrow Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. Drug Target Sites Cell wall – Peptidoglycan – Mycolic acid – Fungal beta glucans Cell membrane – Some bacterial proteins – Ergosterol Protein synthesis – 70S ribosomes Nucleic acid synthesis – DNA gyrase – RNA - viral enzymes Antimetabolite – Bacterial folic acid Copyright © 2012 John Wiley & Sons, Inc. All rights .
