This research contributes to the synthetic method of quinoline-4(1H)-one ring by Conrad-Limpach method with the use of vegetable oils as high boiling-point solvents, which are friendly-environmental, and not expensive friendlyenvironmental. The structures of different substituted 4(1H)-quinolin-4-ones have been confirmed by using spectroscopic methods (IR, 1H and 13C NMR). | VNU Journal of Science: Natural Sciences and Technology, Vol. 32, No. 4 (2016) 124-129 Study on the use of commercial vegetable oils as green solvents in synthesis of 2-methyl-4(1H)-quinolin-4-ones Nguyen Dinh Thanh1,*, Le The Duan2, Tran Thi Thanh Van1, Pham Mai Chi1, Luu Son Quy1, Pham Thi Anh1, Dang Thi Thu Hien1 1 2 Faculty of Chemistry, VNU University of Science High School for Gifted Students, VNU University of Science Received 08 July 2016 Revised 19 August 2016; Accepted 01 Septeber 2016 Abstracts: Some substituted 2-methyl-4(1H)-quinolin-4-ones have been prepared from corresponding ethyl β-(substituted)anilinocrotonates. This research contributes to the synthetic method of quinoline-4(1H)-one ring by Conrad-Limpach method with the use of vegetable oils as high boiling-point solvents, which are friendly-environmental, and not expensive friendlyenvironmental. The structures of different substituted 4(1H)-quinolin-4-ones have been confirmed by using spectroscopic methods (IR, 1H and 13C NMR). Keywords: Conrad-Limpach synthesis, 2-methyl-4(1H)-quinolin-4-ones, vegetable oils. 1. Introduction* making quinolones useful for the treatment of urinary, systemic and respiratory tract infections [4]. Insertion of some functional groups, such as formyl or chloride, could help us to bind other helpful molecular moieties into quinolone molecule. Substituted 2-methyl4(1H)-quinolin-4-ones are needed precursors for our further researches, therefore, in this paper we reported the friendly-environmental large-scale synthesis of these quinolones from ethyl β-(substituted)anilinocrotonates using vegetable oils as high boiling-point solvents. Quinolones have been the subject of continuous academic interest and various structural modifications have resulted in second, third and fourth-generation quinolone antibiotics which are currently used in disease treatments [1], for example ciprofloxacin, is the most consumed antibacterial quinolone worldwide [2]. The bark of .
