Objectives: To investigate serum levels of some inflammatory markers (CRP-hs, C3, C4, and Interleukin (IL)-6 in patients with acute coronary syndrome (ACS). Subjects and Methods: Serum levels of CRP-hs, C3, C4, and IL-6 in blood samples taken from 100 patients with ACS (on hospital admission, and at 6 months after treatment) and 50 healthy people (served as normal controls) were quantified using immuno-chemiluminescense technique. | Journal of military pharmaco-medicine no1-2018 RESEARCH ON CHANGES IN LEVELS OF NON-SPECIFIC INFLAMMATORY MARKERS IN PATIENTS WITH ACUTE CORONARY SYNDROME Nguyen Thi Thanh Thuy*; Pham Nguyen Vinh**; Pham Manh Hung*** SUMMARY Objectives: To investigate serum levels of some inflammatory markers (CRP-hs, C3, C4, and Interleukin (IL)-6 in patients with acute coronary syndrome (ACS). Subjects and Methods: Serum levels of CRP-hs, C3, C4, and IL-6 in blood samples taken from 100 patients with ACS (on hospital admission, and at 6 months after treatment) and 50 healthy people (served as normal controls) were quantified using immuno-chemiluminescense technique. Results: Serum levels of CRP-hs, C3, C4, and IL-6 were significantly higher in patients with ACS compared to those in controls. After 6 months of conventional treatment, CRP-hs and IL-6 levels significantly decreased compared to those before treatment. Conclusions: Serum level of IL-6 và CRP-hs in patients with ACS reflected the treatment response, and thus, may serve as biomarkers for treatment evaluation in patients with ACS * Keywords: Coronary artery disease; Acute coronary syndrome; Inflammatory markers. INTRODUCTIONS Coronary artery disease (CAD) is one of the diseases that has increased in prevalence and become more common in developed as well as developing countries, including Vietnam. The disease is believed to account for a large number of death in hospital inpatients. CAD includes ACS and stable coronary artery disease. Pathogenesis of CAD involves artherosclerosis with damaged vessel wall of the coronary arteries, leading to vessel occlusion by thrombosis, and eventually, myocardial infarction [3, 8]. Recent data showed that inflammation plays an important role in initiation as well as progression of ACS [6, 7]; investigation of level of inflammatory markers in serum of patients with ACS would be of importance in elucidating the pathogenesis of the disease. Among the inflammatory markers, CRP-hs has .
