Objectives: To determine clinical and paraclinical manifestations and outcome of severe burn patient with acute respiratory distress syndrome. Subjects and methods: A prospective study was conducted on 66 severe burn patients with acute respiratory distress syndrome (ARDS), treated at Burn Intesive care Unit, National Institute of Burns from 11 - 2013 to 10 - 2016. | Journal of military pharmaco-medicine no7-2017 CHARACTERISTICS AND OUTCOME OF ACUTE RESPIRATORY DISTRESS SYNDROME AMONG SEVERE BURN PATIENTS Tran Dinh Hung*; Dong Khac Hung**; Nguyen Nhu Lam* SUMMARY Objectives: To determine clinical and paraclinical manifestations and outcome of severe burn patient with acute respiratory distress syndrome. Subjects and methods: A prospective study was conducted on 66 severe burn patients with acute respiratory distress syndrome (ARDS), treated at Burn Intesive care Unit, National Institute of Burns from 11 - 2013 to 10 - 2016. Diagnosis of ARDS was based on the Berlin criteria in 2012. Clinical and paraclinical manifestations of the patients at ARDS onset until discharged or death were recorded and analyzed. Results: Over a half () of ARDS cases developed during the first week post burn. Most of cases were classified as moderate and severe levels ( and , respectively). Common characteristics were mental disorder (), fever, leukocytosis (), dyspnea, tachypnea, diffuse rales, cyanosis, tachycardia, chest pain and dry cough. Fully bilateral alveolar infiltrate on chest radiograph was recorded in of cases. Plasma cytokine levels (IL1-β, IL-6, IL-8, IL-10 and TNF-α) increased significantly since admission and prolonged. Overall mortality rate was with the main cause of multiple organ failure (56%). Conclusion: ARDS was a serious complication post burn with typical acute pulmonary abnormalities, significantly prolong raising plasma cytokines levels and high mortality rate due to multiple organ failure. * Keywords: Burn; Acute respiratory distress syndrome; Characters. INTRODUCTION Acute respiratory distress syndrome which was first described by Ashbaugh et al in 1967 characterized by acute onset, severe hypoxemia with bilateral infiltrate and non-hydrostatic pulmonary edema [1]. In 1994, a formal definition and classification of ARDS was reported by the American-European Consensus Conference
