Subjects and methods: A clinical trial study was conducted on 70 workers in some military factories with the evidence of trinitrotoluene (TNT) in their blood from October 2014 to April 2015. The non-specific detoxification method had been applied according to the scientific principle of the Hubbard method for 3 weeks. | Journal of military pharmaco-medicine STUDY ON CHANGING CONCENTRATION OF TNT AND SOME CYTOKINES IN WORKERS OCCUPATIONALLY EXPOSED TO TNT AFTER NON-SPECIFIC DETOXIFICATION TREATMENT Nguyen Kien Cuong*; Nguyen Phuc Thai*; Do Phuong Huong** Nguyen Xuan Kien***; Nguyen Minh Phuong**** SUMMARY Subjects and methods: A clinical trial study was conducted on 70 workers in some military factories with the evidence of trinitrotoluene (TNT) in their blood from October 2014 to April 2015. The non-specific detoxification method had been applied according to the scientific principle of the Hubbard method for 3 weeks. Results: Mean TNT concentration before treatment was (µg/mL) and reduced sharply down to (µg/mL) after treatment. The difference was statistically significant (p < ). Mean concentration of erythropoietin (EPO) pre-treatment was (pg/mL) and rose (pg/mL) after the treatment (p < ). Mean erythropoietin receptor (EPOR) before treatment was (pg/mL) and increased up to (pg/mL) after treatment, the difference was statistically significant (p < ). Mean concentration of interferon gamma (IFN-γ) was (pg/mL) before treatment and reached (pg/mL) after the detoxification (p < ). * Keywords: TNT; Detoxification; Occupational exposure; Women; Erythropoietin; Erythropoietin receptor; Interferon gamma. INTRODUCTION Trinitrotoluene has been widely used in the defense with the large number of workers directly exposed to TNT. Until now, there is no specific detoxification treatment for TNT. TNT not only damages the blood cells in bone marrow and periferal [11] but also inhibites the body's immune system [4]. Prophylaxis of occupational TNT toxicity plays an important role in ensuring the health of workers exposed to TNT. Hubbard has successfully researched and applied non-specific detoxification method to a variety of lipidsoluble chemicals such as chlorobenzocyclic hydrocarbons (PCBs ), heavy .
