Research target: We conducted the research to determine the distribution of 131I-nimotuzumab through the indication of the radioactivity in tissues of nude mice bearing human head and neck cancer tumors. | JOURNAL OF MILITARY PHARMACO-MEDICINE No7-2015 BIODISTRIBUTION OF MONOCLONAL ANTIBODY NIMOTUZUMAB LABELED 131I ON NUDE MICE BEARING HUMAN HEAD AND NECK CANCER Nguyen Thi Kim Huong*; Ho Anh Son**; Nguyen Thi Thu*** Pham Huy Quyen*; Nguyen Linh Toan** SUMMARY 131 Research target: We conducted the research to determine the distribution of I-nimotuzumab through the indication of the radioactivity in tissues of nude mice bearing human head and neck 131 cancer tumors. Subject and methods: The I-nimotuzumab was injected into the mice’s veins at the dose of 100 µCi per mouse, and radioactivity was counted at three time points: 24, 48, and 72 hours after the injection. Results: The research results showed that all the tissues and organs manifested the radioactivity. In tumor, the radioactivity count was higher than that of any other organs. The highest indication was 48 hours after the injection, and then gradually declined. Radioactivity of the tumor was 79,26% compared to blood count at 72 hours after the 131 injection. Conclusion: With blood normalize, distribution of I-nimotuzumab in tumors is the highest compared with other tissues and organs of the nude mice. * Key words: Head and neck cancer; Monoclonal antibody nimotuzumab labeled INTRODUCTION Head and neck cancer is a disease with high incidence in the world, as well as in Vietnam, about 10% of annual cancer patients diagnosed with head and neck cancer among total number of cancer patients [1]. Head and neck cancer is varied and complex, expressed in multiple locations, offices, including throat cancer, mouth floor, lowering the larynx and throat, salivary glands, tongue, thyroid., causing the rear significant effects on health, the patient lives if not diagnosed early and treated promptly. Head and neck cancer has higher expression amount of EGFR (EGFR: Epidermal Growth Factor Receptor) I; Nude mice. in an unusual way, is one of the important pathogenetic factors of growth, invasion excessive encroachment .
