Objectives: Amyloid beta 1-42 (Aβ 1-42) is related to several disorders including nervous, cardiovascular and metabolic disorder. We investigated plasma Aβ 1-42 level and examined its correlation with some cardiovascular risk factors. | Journal of military pharmaco-medicine No7-2016 INVESTIGATION OF PLASMA AMYLOID BETA 1-42 LEVELS AND ITS CORRELATION WITH SOME CARDIOVASCULAR RISK FACTORS IN PEOPLE OVER FORTY YEARS OLD Nguyen Minh Hai*; Nguyen Minh Nui*; Ho Anh Son** SUMMARY Objectives: Amyloid beta 1-42 (Aβ 1-42) is related to several disorders including nervous, cardiovascular and metabolic disorder. We investigated plasma Aβ 1-42 level and examined its correlation with some cardiovascular risk factors. Subjects and methods: Level of Aβ 1-42 was measured in plasma of 40 people over forty years old without type 2 diabetes mellitus and hypertension by ELISA method. Results and conclusions: Average plasma Aβ 1-42 level was ± pg/mL, median was pg/mL with wide range from to pg/mL. There was no significant correlation between plasma Aβ 1-42 level and cardiovascular risk factors such as age, plasma lipids. * Key words: Metabolic disorder; Amyloid beta. INTRODUCTION Amyloid is a specific peptide family including aggregating beta chains. Small, focal, clinically silent amyloid deposits in the brain, heart, seminal vesicles, and joints is a universal accompaniment of aging. These results in amyloidosis, structural disorders, reduction and loss in function of various organs in the body. The underlying molecular abnormalities may be either acquired or hereditary and about 20 different proteins can form clinically or pathologically significant amyloid fibrils in vivo. Brain amyloid deposit is a major pathological feature of Alzheimer disease. Islet amyloid deposits trigger type 2 diabetes mellitus. Amyloid also deposits in joints, peripheral arteries, kidneys. Aβ 1-42 is one of amyloid molecular, which is considered to relate with different diseases such as Alzheimer’s disease, diabetes, cardiovascular diseases [2]. Although many studies about Aβ 1-42 have been performed, its role and physical function is still unknown. So far in Vietnam, there has been no investigation about
