A study on the rate and some risk factors causing gene EGFR mutation in lung adenocarcinoma was conducted at Bachmai Hospital. Objectives: To determine the rate and risk factors for EGFR gene mutations on 152 patients with lung adenocarcinoma at Bachmai Hospital. | Journal of military pharmaco-medicine No7-2016 STUDY ON RATE AND SOME RISK FACTORS FOR EGFR MUTATION IN 152 PATIENTS WITH LUNG ADENOCARCINOMA AT BACHMAI HOSPITAL Nguyen Thi Lan Anh*; Nguyen Huy Binh* Mai Trong Khoa*; Dong Khac Hung** SUMMARY A study on the rate and some risk factors causing gene EGFR mutation in lung adenocarcinoma was conducted at Bachmai Hospital. Objectives: To determine the rate and risk factors for EGFR gene mutations on 152 patients with lung adenocarcinoma at Bachmai Hospital. Subjects and methods: 152 patients with lung adenocarcinoma diagnosed by histopathological method; the mutation of EGFR gene was identified by assay Strip methods. Results: 60 lung cancer patients () were diagnosed adenocarcinoma. The rate of mutations was found at exons 18, 19, 20, 21 of the EGFR gene. The exon mutations were classified as follows: G719S mutation, G719C (exon 18), LREA deletion (exon 19), T790M (exon 20) and L858R; L861Q (exon 21) were , , and , respectively. The possibility of EGFR gene mutations in female patients was times as high as male patients (95%CI to ) and fold higher compared to patients with history of smoking with 95%CI: to . Conclusions: Among 152 patients with lung adenocarcinoma who were treated at Bachmai Hospital, we found the rate of EGFR gene mutations was . The mutations of EGFR gene were more common in women and non-smoking patients. * Key words: Lung adenocarcinoma; EGFR gene mutation; Gender; Smoking. INTRODUCTION In Vietnam, lung cancer is one of the most common malignant diseases in both men and women and is also the leading cause of death from cancer. The prevalence of lung cancer is in men and in women [1]. Disease-free survival and overall survival rate of lung cancer patients is still very low, although there have been many advances in diagnosis and treatment [3, 4, 5]. Currently, adenocarcinoma is the most common type of lung cancer in Vietnam
