Bài viết trình bày về Aflatoxin là độc tố thứ cấp gây ung thư được sản sinh bởi hai chủng nấm chính là Aspergillus flavus và Aspergillus parasiticus. Đây là những loài nấm gây nguy hiểm tới sức khỏe con người và là nguyên nhân chính gây tổn thất và ô nhiễm trong quá trình chế biến thực phẩm và thức ăn chăn nuôi,. . | Vietnam J. Agri. Sci. 2016, Vol. 14, No. 10: 1581 -1587 Tạp chí KH Nông nghiệp Việt Nam 2016, tập 14, số 10: 1581 - 1587 EFFECT OF TRICHODERMA sp. TC1 AND ITS EXTRACT ON GROWTH INHIBITION AND AFLATOXIN PRODUCTION OF Aspergillus flavus AND Aspergillus parasiticus Nguyen Thi Thanh Thuy1*, Luu Thi Phuong Thao2, Vu Quynh Huong1, Nguyen Van Giang2 1 Faculty of Food Science and Technology, Vietnam National University of Agriculture 2 Faculty of Biotechnology, Vietnam National University of Agriculture Email*: nttthuycntp@ Received date: Accepted date: ABSTRACT Aflatoxins are toxic carcinogenic secondary metabolites produced predominantly by two fungi: Aspergillus flavus and Aspergillus parasiticus. These fungi are a health risk and are responsible for losses and contamination of processed foods and feeds. It is very important to find methods to inhibit the growth of A. flavus and A. parasiticus, and degrade aflatoxin. In laboratory conditions, the Percentages of Inhibition of Radial Growth (PIRG %) of Trichoderma sp. TC1 against A. flavus LA21 and A. parasiticus NG10 after 7 days’ dual culture were and , respectively. However, the use of Trichoderma mycelium has restrictions in agricultural products due to the risks of consuming the substrate and degrading the products’ quality. Therefore, its extracts are more preferred in application. In the PD media, when up to 4% Trichoderma sp. TC1 extract was added, the biomass rate for A. flavus LA21 and A. parasiticus NG10 reduced to and , respectively, after 5 days of incubation. The toxin levels of corn samples deliberately infected by aflatoxin producing fungi were negatively correlated with sprayed on Trichoderma sp. TC1 extract. Seven days after spraying the extract 4%, the aflatoxin in samples from more than 60 ppb at the initial time reduced down to 16 ppb for A. flavus LA21 and ppb for A. parasiticus NG10. Keywords: Aflatoxin, .