Trong nghiên cứu này, huyền phù của curcumin dạng kích thước submicron đã được điều chế trong dung môi là nước mà không cần phải thêm bất cứ phụ gia nào. Kích thước trung bình của các hạt phân tán curcumin vào khoảng 546 nm (xác định bằng phương pháp DLS). Kết quả nghiên cứu cho thấy có thể sử dụng huyền phù curcumin dạng submicron với một số phụ gia hoặc hóa chất thường gặp trong các sản phẩm thực phẩm mà độ bền của curcumin dạng submicron không bị ảnh hưởng. Hệ huyền phù chỉ chứa curcumin và nước, nên hứa hẹn có nhiều ứng dụng trong các lĩnh vực thực phẩm chức năng, mỹ phẩm và dược phẩm. | Science & Technology Development, Vol 14, 2011 STABILITY OF ‘SUBMICRON CURCUMIN’ FROM CURCUMA LONGA L. IN AQUEOUS MEDIA Le Thi Hong Nhan, Truong Thi Hai Au, Vuong Ngoc Chinh, Phan Thanh Son Nam University of Technology, VNU-HCM (Manuscript Received on May 13th, 2011, Manuscript Revised November 01st, 2011) ABSTRACT: Curcuma Longa L. has been considered as an excellent source of curcumin, having wide scale applications in pharmaceutical, food and cosmetic industry. However, widespread applications of this relatively efficacious agent have been limited due to the poor aqueous solubility, and consequently, minimal systemic bioavailability. In this research, ‘submicron curcumin’ suspension in aqueous media was prepared from Curcuma longa L. without the presence of any additive. The average diameter of the ‘submicron curcumin’ particles was 546 nm (DLS). It was found that the ‘submicron curcumin’ suspension could be used in conjunction with several common food ingredients with its stability remaining unaffected. As the system only contained ‘submicron curcumin’ and water, it would be highly promising to applications in functional food, cosmetic, and pharmaceutical industries. Keywords: Curcuma Longa L. with 1. INTRODUCTION Curcumin has attracted a considerable macromolecules polysaccharides and including gelatins, phospholipids were attention in recent years due to its great variety previously reported [2,3]. However, toxic of beneficial biological and pharmacological organic solvents were still present in these activities [1]. Besides its effective antioxidant, procedures. antitumor, anti-inflammatory, anticarcinogenic As curcumin is used in foods and traditional and free radical scavenger properties, it is also medicines, believed that curcumin is a potent agent against approaches to improve the solubility and many diseases such as anorexia, rheumatism, stability of curcumin in aqueous media is and significantly necessary. Recently,
