This lecture includes these contents: Critical appraisal of systematic reviews, appraise a systematic review for validity, relative risk reduction, number needed to treat, why odds ratios,. Invite you to consult this lecture. | Critical Appraisal of Systematic Reviews Douglas Newberry Systematic Reviews — or How to make a Monkey out of EBM without hardly trying! Systematic Reviews: Objectives: Appraise a systematic review for validity Discuss Meta Analysis / use Odds Ratios Obtain Number Needed to Treat (NNT) from Odds Ratios Consider clinical implications of a Systematic Review {including when to bin it instead!} We can see further than our forbearers because we stand on the shoulders of Giants {and have better spectacles} these ideas are cribbed unashamedly from friends, books & previous courses Systematic Reviews: What are your Objectives: What do you want to cover? Please interject with helpful questions! Did I really want a systematic review? (but please do not pretend) admit your ignorance — expert review or consensus guidelines > broad introduction, cover many areas (class C evidence). if the question is important > formulate it! Systematic review > narrow but rigorous focus. BMJ ABC series are mainly expert based reviews giving a broad, sensible introduction to a wide clinical area. These are rarely systematic reviews Textbooks can function in same way. Remember this is usually class C evidence. Move on to define your (or your patient’s) key question Systematic Reviews — Where do I start: Start with your 4 (or 3) part clinical question! Is a systematic review a sensible approach? Does THIS systematic review address MY question? Is it a systematic review at all? Is it a systematic review? does it: define a four part (answerable) clinical question? combine Randomized Controlled Trials (RCT’s)? describe PRE-DEFINED search methods? PRE-DEFINED inclusion criteria? PRE-DEFINED methodological exclusion criteria? Sceptical View? Take it with a grain of salt: transparent declaration of funding of work? Drug Company sponsorship of Reviews vs. Methodological quality>Cochrane review! who employs the authors? open discussion of existing controversy & commercial gain? Don’t waste salt on . | Critical Appraisal of Systematic Reviews Douglas Newberry Systematic Reviews — or How to make a Monkey out of EBM without hardly trying! Systematic Reviews: Objectives: Appraise a systematic review for validity Discuss Meta Analysis / use Odds Ratios Obtain Number Needed to Treat (NNT) from Odds Ratios Consider clinical implications of a Systematic Review {including when to bin it instead!} We can see further than our forbearers because we stand on the shoulders of Giants {and have better spectacles} these ideas are cribbed unashamedly from friends, books & previous courses Systematic Reviews: What are your Objectives: What do you want to cover? Please interject with helpful questions! Did I really want a systematic review? (but please do not pretend) admit your ignorance — expert review or consensus guidelines > broad introduction, cover many areas (class C evidence). if the question is important > formulate it! Systematic review > narrow but rigorous focus. BMJ ABC series are .
