This lecture includes these contents: The systematic reviews, methods and procedures, features of narrative reviews and systematic reviews, steps of a cochrane systematic review, synthesis of data,. Invite you to consult this lecture. | Systematic Reviews: Methods and Procedures George A. Wells Editor, Cochrane Musculoskeletal Review Group Department of Epidemiology and Community Medicine University of Ottawa Ottawa, Ontario, Canada Meta-analysis is a statistical analysis of a collection of studies Meta-analysis methods focus on contrasting and comparing results from different studies in anticipation of identifying consistent patterns and sources of disagreements among these results Primary objective: Synthetic goal (estimation of summary effect) vs Analytic goal (estimation of differences) Meta-analysis: Systematic Review: the application of scientific strategies that limit bias to the systematic assembly, critical appraisal and synthesis of all relevant studies on a specific topic Meta-Analysis: a systematic review that employs statistical methods to combine and summarize the results of several studies Features of narrative reviews and systematic reviews QUESTION Broad Focused SOURCES/ Usually unspecified . | Systematic Reviews: Methods and Procedures George A. Wells Editor, Cochrane Musculoskeletal Review Group Department of Epidemiology and Community Medicine University of Ottawa Ottawa, Ontario, Canada Meta-analysis is a statistical analysis of a collection of studies Meta-analysis methods focus on contrasting and comparing results from different studies in anticipation of identifying consistent patterns and sources of disagreements among these results Primary objective: Synthetic goal (estimation of summary effect) vs Analytic goal (estimation of differences) Meta-analysis: Systematic Review: the application of scientific strategies that limit bias to the systematic assembly, critical appraisal and synthesis of all relevant studies on a specific topic Meta-Analysis: a systematic review that employs statistical methods to combine and summarize the results of several studies Features of narrative reviews and systematic reviews QUESTION Broad Focused SOURCES/ Usually unspecified Comprehensive; SEARCH Possibly biased explicit SELECTION Unspecified; biased?Criterion-based; uniformly applied APPRAISAL Variable Rigourous SYNTHESIS Usually qualitative Quantitative INFERENCE Sometimes Usually evidence- evidence-based based NARRATIVE SYSTEMATIC Steps of a Cochrane Systematic Review Clearly formulated question Comprehensive data search Unbiased selection and extraction process Critical appraisal of data Synthesis of data Perform sensitivity and subgroup analyses if appropriate and possible Prepare a structured report What is the study objective to validate results in a large population to guide new studies Pose question in both biologic and health care terms specifying with operational definitions population intervention outcomes (both beneficial and harmful) Inclusion Criteria Study design Population Interventions Outcomes Steps of a Cochrane Systematic Review Clearly formulated question Comprehensive data search Unbiased selection and extraction process Critical .
