This review also describes some experimental models, application and discuss the functional and biological mechanisms of AOS. In conclusion, AOS promotes beneficial effects on the immuno-metabolic response to various infectious diseases as well as it is promising as a biomaterial for functional foods and medicinal drugs development. | Vietnam Journal of Science and Technology 56 (2) (2018) 133-147 DOI: MARINE ALGINATE OLIGOSACCHARIDES – A PROMISING BIOMATERIAL: CURRENT USE AND FUTURE PERSPECTIVES IN FOOD INDUSTRY AND PHARMACEUTICAL APPLICATIONS Tran Van Cuong1, 3, *, Nguyen Thi Thoa2, Kim Duwoon3, * 1 Faculty of Agriculture and Forestry, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Daklak, Viet Nam 2 3 The Western Highland Agriculture and Forestry Science Institute, 53 Nguyen Luong Bang, Buon Ma Thuot, Daklak, Viet Nam Department of Food Science and Technology, Chonnam National University, Gwangju 61186, South Korea * Email: Received: 9 June 2017; Accepted for publication: 27 December 2017 Abstract. Alginate oligosaccharides (AOS) have been known as a natural material with a wide variety of biological activities, and used for a long time. The evidence of using AOS to confer health benefits have been documented. The isolation and characterization of the properties, biological activity as well as the applications of AOS in various fields have been studied recently. In present work, we provide the recent research of AOS, particularly focusing on the applications in food and medicinal industry. This review also describes some experimental models, application and discuss the functional and biological mechanisms of AOS. In conclusion, AOS promotes beneficial effects on the immuno-metabolic response to various infectious diseases as well as it is promising as a biomaterial for functional foods and medicinal drugs development. Keywords: alginate, alginate oligosaccharide, biological activity, marine drug, molecular mechanism. Classification numbers: ; ; 1. INTRODUCTION Marine algae are recognized as a rich source of alginate, a polysaccharide with high biodiversity serving numerous biological applications. It has been known that alginates are produced from two sources, algae and bacteria [1]. However, according to Goh et
