In the search for bioactive constituents from Vietnamese plants, the leaves and stems of Callistemon citrinus (Curtis) Skeels were selected for chemical investigation. Phytochemical analysis of plant led to the isolation of eight phenolic compounds including two flavonoids (eucalyptine (1) and 8-demethyleucalyptine (2)), two alcohols (blumenol A (3), ntetratriacontanol (4)), three benzoic acid derivatives (acid gallic (5), methyl gallate (6) protocatechuic acid (7)), one sterol (β-sitosterol (8)), and along with one sesquiterpene (2,6,10- bisabolatriene (9)). The structures of the natural compounds were determined from the spectroscopic evidences including 1D- and 2D-NMR and ESI-MS. | Journal of Science and Technology 54 (2) (2016) 190-197 DOI: PHENOLIC COMPOUNDS FROM CALLISTEMON CITRINUS LEAVES AND STEMS Pham Ngoc Khanh1, Ho Viet Duc2, Tran Thu Huong1, Vu Thi Ha1, Doan Thi Van1, Ninh The Son1, Young Ho Kim3, Do Quoc Viet4, Nguyen Manh Cuong1, * 1 Department of Bioactive Compounds, Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 2 Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Vietnam 3 4 College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi * Email: nmcuong_inpc@ Received: 25 June 2015; Accepted for publication: 2 January 2016 ABSTRACT In the search for bioactive constituents from Vietnamese plants, the leaves and stems of Callistemon citrinus (Curtis) Skeels were selected for chemical investigation. Phytochemical analysis of plant led to the isolation of eight phenolic compounds including two flavonoids (eucalyptine (1) and 8-demethyleucalyptine (2)), two alcohols (blumenol A (3), ntetratriacontanol (4)), three benzoic acid derivatives (acid gallic (5), methyl gallate (6) protocatechuic acid (7)), one sterol (β -sitosterol (8)), and along with one sesquiterpene (2,6,10bisabolatriene (9)). The structures of the natural compounds were determined from the spectroscopic evidences including 1D- and 2D-NMR and ESI-MS. Keywords: Callistemon citrinus (Curtis) Skeels, flavonoid, triterpenoid. 1. INTRODUCTION The Myrtaceae family in Vietnam comprises about 30 genera, several of which are very common and widely distributed throughout the country such as Eucalyptus, Rhodomyrtus, Syzygium, and Callistemon [1]. Species Callistemon citrinus (Curtis) Skeels, local name “Tram bong do”, is grown as ornaments in Vietnam for its beautiful form, glossy green foliage and .
