From the rhizomes of Curcuma singularis Gagnep (Zingiberaceae family), six compounds, including three terpenoids, p-menthane-1,2,4-triol (1), amoxantin A (2), rugosic acid B (3); two diols, 2,3-butanediol (4) [2R,3R-butanediol (4a) and 2S,3S-butanediol (4b)], and meso-2,3- butanediol (5), along with 3-hydroxy-4-methoxy benzoic acid (6) were isolated. All of six compounds were obtained for the first time from the Curcuma genus. The structures of those compounds were determined by 1D and 2D-NMR spectroscopic data. | Journal of Science and Technology 54 (2C) 2016 402-408 INITIAL RESEARCH ON CHEMICAL CONSTITUENTS OF CURCUMA SINGULARIS RHIZOMES Nguyen Manh Cuong1, *, Doan Thi Van1, Ninh The Son1, To Dao Cuong1, Pham Ngoc Khanh1, Vu Thi Ha1, Tran Thu Huong1, Nguyen Phuong Hanh2, Nguyen Quoc Binh3 1 2 Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi 3 Vietnam National Museum of Nature, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi * Email: nmcuong_inpc@ Received: 20 May 2016; Accepted for publication: 28 October 2016 ABSTRACT From the rhizomes of Curcuma singularis Gagnep (Zingiberaceae family), six compounds, including three terpenoids, p-menthane-1,2,4-triol (1), amoxantin A (2), rugosic acid B (3); two diols, 2,3-butanediol (4) [2R,3R-butanediol (4a) and 2S,3S-butanediol (4b)], and meso-2,3butanediol (5), along with 3-hydroxy-4-methoxy benzoic acid (6) were isolated. All of six compounds were obtained for the first time from the Curcuma genus. The structures of those compounds were determined by 1D and 2D-NMR spectroscopic data. Keywords: Curcuma singularis Gagnep., Zingiberaceae, rhizomes, terpenoid, labdadien, butanediol, benzoic acid. 1. INTRODUCTION Curcuma is a large genus belonging to Zingiberaceae family, comprise of 147 species over the world [1] and 15 species in Vietnam [2]. Several Curcuma species were used in traditional medicine for the treatment of gastrointestinal disorders, abdominal pain, jaundice, and hepatitis [3]. Curcuma singularis Gagnep., local name “cây khỏe” were used by ethnic people in Tay Nguyen provinces as medicinal remedy for increasing vitality, boosting health, treating rheumatism and fortifying kidney. Around the world, so far there have been many publications on the chemical compositions and biological activity of the Curcuma species such as Curcuma longa L. [4, 5], C. wenyujin [6], and C. comosa [7]. Compounds .
