Cordyceps is a well-known traditional medicine to heal various serious diseases for centuries. Besides, polysaccharides isolated from Cordyceps had demonstrated to exhibit potential bioactivities, especially antioxidant activity. Hence, this study concentrated on the antioxidant effects of exopolysaccharides (EPS) isolated from ten kinds of Cordyceps cultured broth. Consequently, Cordyceps sinensis cultured broth possessed the highest EPS as well as total carbohydrate content, but the nearly lowest protein content ( g/l, % and % respectively). | Journal of Science and Technology 54 (4A) (2016) 148-155 COMPARISON OF RADICALS SCAVENGING ACTIVITY OF EXOPOLYSACCHARIDES FROM CULTURED CORDYCEPS SPP. ISOLATED IN VIET NAM Phuong-Tham Ho-Thi1, Thi-Tuoi Vu1, Thu Huynh2, *, Minh-Trang Tran1, Thuy-Hang Le-Thi3, Minh-Hiep Dinh4 1 University of Science, Vietnam National University HCMC, 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City 2 University of Technology, Vietnam National University HCMC, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City 3 HCMC University of Food Industry, 140 Le Trong Tan Street, Tan Phu District, Ho Chi Minh City 4 Management Board of Agricultural Hi-Tech Park HCMC, 23 – 25 Ham Nghi Street, District 1, Ho Chi Minh City * Email: huynh_thu@ Received: 15 August 2016; Accepted for publication: 6 October 2016 ABSTRACT Cordyceps is a well-known traditional medicine to heal various serious diseases for centuries. Besides, polysaccharides isolated from Cordyceps had demonstrated to exhibit potential bioactivities, especially antioxidant activity. Hence, this study concentrated on the antioxidant effects of exopolysaccharides (EPS) isolated from ten kinds of Cordyceps cultured broth. Consequently, Cordyceps sinensis cultured broth possessed the highest EPS as well as total carbohydrate content, but the nearly lowest protein content ( g/l, % and % respectively). Most of EPSs exhibited potential radical - scavenging activities suggesting that EPSs would have been regarded as antioxidant resources. Nonetheless, the EPS from DL0067 possessed the highest ABTS radicals scavenging activity (IC50 value = ± µg/ml) but low hydroxyl radicals scavenging activity (IC50 value > 5,000 µg/ml). The EPS from DL0075, in contrast, exhibited the highest hydroxyl radicals scavenging activity (IC50 value = ± µg/ml). All in all, the experiments were indicated higher antioxidant activities of EPS from Cordyceps isolated in Viet Nam than those from Cordyceps .
