From the methanol extract of Bischofia javanica Blume leaves, five compounds including 5'-β-D-glucopyranosyloxyjasmonic acid methyl ester (1), 2-(4-hydroxy-3-methoxyphenyl)ethylO-β-D-glucopyranoside (2), hexyl-O-β-D-glucopyranoside (3), friedelan-3-one (4), and gallic acid (5) were isolated. Their structures were elucidated by NMR spectra as well as in comparison with previously reported data. This is the first report on the isolation of 1, 2, and 3 from Bischofia javanica. | Journal of Science and Technology 55 (2) (2017) 188-194 DOI: AN INITIAL STUDY ON CHEMICAL CONSTITUENTS OF BISCHOFIA JAVANICA Nguyen Thi Mai University of Transport and Communications, 3 Cau Giay, Lang Thuong, Dong Da, Ha Noi * Email: maidhgt@ Received: 25 July 2016; Accepted for publication: 22 February 2017 ABSTRACT From the methanol extract of Bischofia javanica Blume leaves, five compounds including 5'-β -D-glucopyranosyloxyjasmonic acid methyl ester (1), 2-(4-hydroxy-3-methoxyphenyl)ethylO-β-D-glucopyranoside (2), hexyl-O-β-D-glucopyranoside (3), friedelan-3-one (4), and gallic acid (5) were isolated. Their structures were elucidated by NMR spectra as well as in comparison with previously reported data. This is the first report on the isolation of 1, 2, and 3 from Bischofia javanica. Keyword: Bischofia javanica, jasmonic acid derivative, phenylethanoid. 1. INTRODUCTION Bischofia javanica Blume species, belonging to the family Euphorbiaceae, is found widely in Vietnam, India, China, Indonesia, and Philippine [1]. In folk medicinal remedies, B. javanica was used for treatment of various diseases such as cancer, inflammation, tuberculosis, diarrhea, sore throat, burns and different allergic conditions. The barks, leaves, roots, and fruits of this plant are used to treat diphtheria, pharyngitis, tonsillitis, different skin diseases, and nervous disorders [2]. Antileukemic activity of the leaves extract of B. javanica was evaluated on human leukemic cell lines by Lingadurai et al. The methanol extract of this plant showed significant cytotoxicity against HL-60 cell line with an IC50 value as low as µg/ml. In addition, methanol extract B. javanica (10 µg/ml) was demonstrated to induce apoptosis of HL-60 cancer cells which was strongly supported for the ethno-medicinal use of B. javanica leaves in the treatment of cancer [3]. Betulinic acid and its derivatives from chloroform extract of the bark of B. javanica were .
