The phytochemical investigation of the ethyl acetate extract of Pinus kesiya Royle ex Gordon roots led to the isolation of two abietane diterpenes, 7-oxo-15-hydroxy-dehydroabietic acid (1) and dehydroabietic acid (2) as well as two neolignans, cedrusin (3) and cedrusin-4-O-β-D-glucopyranoside (4). Their structures were determined by combination of spectral analysis and comparison with reported data. Among them, compound 1 was isolated from the genus Pinus for the first time. | Vietnam Journal of Chemistry, International Edition, 55(2): 240-243, 2017 DOI: Abietane diterpenoids and neolignans from the roots of Pinus kesiya Nguyen Hoang Sa1,3, Nguyen Thanh Tam1,2, Nguyen Thi Hoang Anh1,2, Tran Duc Quan2, Dao Duc Thien2, Tran Van Sung2, Trinh Thi Thuy1,2* 1 Graduate University of Science and Technology, Vietnam Academy of Science and Technology 2 Institute of Chemistry, Vietnam Academy of Science and Technology 3 Khanh Hoa University Received 30 March 2017; Accepted for publication 11 April 2017 Abstract The phytochemical investigation of the ethyl acetate extract of Pinus kesiya Royle ex Gordon roots led to the isolation of two abietane diterpenes, 7-oxo-15-hydroxy-dehydroabietic acid (1) and dehydroabietic acid (2) as well as two neolignans, cedrusin (3) and cedrusin-4-O-β-D-glucopyranoside (4). Their structures were determined by combination of spectral analysis and comparison with reported data. Among them, compound 1 was isolated from the genus Pinus for the first time. Keywords. Pinus kesiya, abietane diterpenes, neolignans, dehydroabietic acid, cedrusin. 1. INTRODUCTION 2. EXPERIMENTAL Pinus is the largest genus in the pine family (Pinaceae), comprising 114 species [1]. There are eight Pinus species in Vietnam and Pinus kesiya Royle ex Gordon (local name known as Thong ba la, Xa nu, Xa nui, Ngo or Tong thu) mostly distributed among Langbiang plateau. This is a large tree, up to over 30 m tall with a bole free of branches for 15-20 m and up to 100 cm in diameter, with a thick, reticulately and deeply fissured bark [2]. In the folk medicine, the turpentine obtained from the resin of pine trees is antiseptic, diuretic. It is also a valuable remedy used internally in the treatment of kidney, bladder complaints, rheumatic affections, coughs, colds, influenza and tuberculosis [3]. So far, only one publication on the chemical composition of this species has been reported. From pinecone of Pinus kesiya .
