Mangiferin was isolated from Vietnamese Mangifera indica leaves. Its antimicrobial activities against the oral bacterium Streptococcus mutans GS-5 were evaluated in terms of inhibition of acid production and biofilm formation. The obtained results indicated that mangiferin at the concentration of mM clearly inhibited acid production by this organism with a final pH value of compared to of the control. The reduction in biofilm biomass was found up to 92 % when it was treated with mM mangiferin. Thus, mangiferin possesses moderate anticaries activity against S. mutans GS-5. | Vietnam Journal of Chemistry, International Edition, 55(5): 623-626, 2017 DOI: Anticaries activity of mangiferin isolated from Mangifera indica leaves in Vietnam Ngo Van Quang1*, Dang Vu Luong1, Do Thanh Xuan1, Quach Minh Thu1 Nguyen Tien Tai1, Nguyen Quang Tam1, Thanh Thi Thu Thuy1, Nguyen Thi Mai Phuong2 1 Institute of Chemistry, Vietnam Academy of Science and Technology (VAST) 2 Institute of Biotechnology, VAST Received 17 April 2017; Accepted for publication 20 October 2017 Abstract Mangiferin (1) was isolated from Vietnamese Mangifera indica leaves. Its antimicrobial activities against the oral bacterium Streptococcus mutans GS-5 were evaluated in terms of inhibition of acid production and biofilm formation. The obtained results indicated that mangiferin at the concentration of mM clearly inhibited acid production by this organism with a final pH value of compared to of the control. The reduction in biofilm biomass was found up to 92 % when it was treated with mM mangiferin. Thus, mangiferin possesses moderate anticaries activity against S. mutans GS-5. Keywords. Mangifera indica, mangiferin, Streptococcus mutans, anticaries activity. 1. INTRODUCTION 2. MATERIALS AND METHODS Streptococcus mutans is a gram-positive cocci shaped bacterium. The facultative anaerobe is commonly found in the human oral cavity, and is a major contributor of tooth decay. The result of decay can greatly affect the overall health of the individual [1]. Streptococcus mutans is the primary causative agent of human dental caries, one of the most popular diseases in human. S. mutans has been characterized as a strong biofilm producer. Mangifera indica, commonly known as mango is a species of flowering plant in the family Anacardiaceae. It is found in the wild in Bangladesh, India and Pakistan where it is indigenous and cultivated varieties have been introduced to other warm regions of the world. The leaves of Mangifera indica have been .
