The result exhibited that all C. neovolkiana extracts almost showed no toxicity effect on HepG2 cells at the concentration of 100 µg/ml. Besides, all C. neovolkiana extracts also were not α-glucosidase inhibitory activity at the concentration from 1000 to 8000 µg/ml. | 106 Science and Technology Development Journal, vol 20, 2017 Screening for some biological activities of Cultured cordyceps neovolkiana Chi-Dung Nguyen, Thu Huynh, Minh-Hiep Dinh Abstract— Cordyceps has been demonstrated to possess a myriad of biological compounds and effects. There are various strains of Cordyceps. In this study, we evaluated some biological activities of cultured Cordyceps neovolkiana extracts. The result exhibited that all C. neovolkiana extracts almost showed no toxicity effect on HepG2 cells at the concentration of 100 µg/ml. Besides, all C. neovolkiana extracts also were not α-glucosidase inhibitory activity at the concentration from 1000 to 8000 µg/ml. However, some extracts had ABTS• free radical scavenging potential with IC50 values between ± and ± µg/ml. In addition, at 200 µg/ml, the EtOH extract exhibited ± % (p 5000 µg/ml, whereas the IC50 value of vitamin C was about 34 ± 1 µg/ml. Compared to antioxidant activities of polysaccharide extract of C. neovolkiana [6], the IC50 values of ABTS free radical scavenging activity of polysaccharide extract of C. neovolkiana was 2952 ± µg/ml. The results in this study showed that the antioxidant activity in vitro of polysaccharide extracts of C. neovolkiana was higher than solvent fraction extracts of C. neovolkiana. Besides, the IC50 values of ABTS free radical scavenging activity of IPS and EPS from Cordyceps sinensis were ± to ± µg/ml, respectively [10]. The comparison exposed higher antioxidant activity of polysaccharide C. sinensis extracts than fraction C. neovolkiana extracts. In addition, Wu et al [13] studied the antioxidant activity of polysaccharide fractions purified from Cordyceps militaris. The result attributed to their electron transfer or hydrogen donating ability. It has been suggested the existence of hydroxyl group in polysaccharides could donate electrons to reduce the radicals to a more stable
