Salvia L. species have been used for the treatment of various inflammatory ailments in traditional medicine. In order to evaluate this ethnobotanical information, water, methanol, n-butanol, acetone, and chloroform extracts from 3 Salvia species (S. fruticosa, S. verticillata, and S. trichoclada) were screened for their anti-inflammatory activity using in vivo experimental models in rats. | E. ÇADIRCI, H. SÜLEYMAN, P. GÜRBÜZ, A. KURUÜZÜM UZ, Z. GÜVENALP, L. Ö. DEMİREZER Turk J Biol 36 (2012) 59-64 © TÜBİTAK doi: Anti-inflammatory effects of different extracts from three Salvia species Elif ÇADIRCI1, Halis SÜLEYMAN1, Perihan GÜRBÜZ2, Ayşe KURUÜZÜM UZ2, Zühal GÜVENALP3, Lütfiye Ömür DEMİREZER2 1 Department of Pharmacology, Faculty of Pharmacy, Atatürk University, Erzurum - TURKEY 2 Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum - TURKEY 3 Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara - TURKEY 4 Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum - TURKEY Received: Abstract: Salvia L. species have been used for the treatment of various inflammatory ailments in traditional medicine. In order to evaluate this ethnobotanical information, water, methanol, n-butanol, acetone, and chloroform extracts from 3 Salvia species (S. fruticosa, S. verticillata, and S. trichoclada) were screened for their anti-inflammatory activity using in vivo experimental models in rats. For this purpose a carrageenan-induced inflammatory paw edema model was used. All extracts demonstrated anti-inflammatory activities; however, n-butanol extract of Salvia fruticosa (syn. S. triloba), which is known as Turkish sage, was found to be the most active. It can be expected that the active flavonoids, phenolic acids, and terpenoids may be responsible for the anti-inflammatory activity of these plants. Key words: Salvia, Lamiaceae, anti-inflammatory activity Salvia türünün farklı ekstrelerinin antienflamatuvar etkileri Özet: Salvia L. türleri geleneksel tıpta birçok enflamatuvar hastalığın tedavisi amacıyla kulanılmaktadır. Bu etnobotanik bilgileri değerlendirmek amacıyla, 3 Salvia türünün (S. fruticosa, S. verticillata ve S. trichoclada) su, metanol, n-butanol, aseton ve kloroform ekstreleri in vivo deneysel sıçan modelleri kullanılarak antienflamatuvar etki .
