Amygdalus lycioides var. horrida (Spach) Browicz (Rosaceae), also known as Prunus lycioides (Spach.) Schneid., is an endemic Iranian species of the genus Amygdalus. In Iranian traditional medicine, the aerial parts and roots of A. lycioides are used in the treatment of diabetes. Six flavonoids, . quercetin 3-O-rhamnoside (1), luteolin 7-O-rhamnoside (2), isorhamnetin 3-O-rutinoside (3), kaempferol 3-O-rhamnoside (4), apigenin (5), and naringenin (6), have been isolated from the aerial parts of this plant. | Turk J Biol 32 (2008) 203-208 © TÜBİTAK Antioxidant and Vasorelaxant Activities of Flavonoids from Amygdalus lycioides var. horrida Hossein BABAEI1, Omid SADEGHPOUR2, Lutfun NAHAR3, Abbas DELAZAR1, Hossein NAZEMIYEH1, Mohammad Reza MANSOURI4, Naser POURSAEID4, Solmaz ASNAASHARI1, Sedigheh Bamdad MOGHADAM1, Satyajit Dey SARKER3,* 1 Faculty of Pharmacy, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz - IRAN 2 Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran - IRAN 3 School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland - UK 4 Faculty of Agriculture, Azad University of Khorasgan, Isfahan - IRAN Received: Abstract: Amygdalus lycioides var. horrida (Spach) Browicz (Rosaceae), also known as Prunus lycioides (Spach.) Schneid., is an endemic Iranian species of the genus Amygdalus. In Iranian traditional medicine, the aerial parts and roots of A. lycioides are used in the treatment of diabetes. Six flavonoids, . quercetin 3-O-rhamnoside (1), luteolin 7-O-rhamnoside (2), isorhamnetin 3-O-rutinoside (3), kaempferol 3-O-rhamnoside (4), apigenin (5), and naringenin (6), have been isolated from the aerial parts of this plant. The structures of these compounds were elucidated by UV, MS, and NMR spectroscopic data analyses. While the antioxidant activity of these compounds was assessed by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay, the vasorelaxant effect was determined using the rat aortic vascular smooth muscle. Compounds 1-6 displayed significant antioxidant activity, with the RC50 values ranging from to mg/ml. Compound 2 showed a considerable vasorelaxant activity on rat aortic vascular smooth muscle in a dose-dependent manner. Key Words: Amygdalus lycioides var. horrida, Rosaceae, flavonoid, antioxidant, DPPH, vasorelaxant Amygdalus lycioides var. horrida Bitkisinin Flavonitlerinin .
