The aim of the current study was to evaluate lead accumulation in the ovaries, fallopian tubes, and uterus and to take note of any consequent histo-architectural changes. The experiment involved a 12-month chronic exposure of 28 Wistar female rats at sexual maturity (221 ± g/individual) to lead acetate in drinking water. | Turkish Journal of Biology Turk J Biol (2015) 39: 284-289 © TÜBİTAK doi: Research Article Effects of long-term exposure of female rats to low levels of lead: ovary and uterus histological architecture changes 1 2 3 4 5 1 Eugenia DUMITRESCU , Viorica CHIURCIU , Florin MUSELIN , Roxana POPESCU , Diana BREZOVAN , Romeo T. CRISTINA 1 Pharmacology and Pharmacy Departments, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timisoara, Romania 2 Drugs Production Department, Romvac Company, Voluntari, Romania 3 Veterinary Toxicology Department, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timisoara, Romania 4 Cellular and Molecular Biology Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania 5 Histology and Molecular Biology Department, Faculty of Veterinary Medicine, Banat’s University of Agriculture and Veterinary Medicine “King Michael I of Romania”, Timisoara, Romania Received: Accepted: Published Online: Printed: Abstract: The aim of the current study was to evaluate lead accumulation in the ovaries, fallopian tubes, and uterus and to take note of any consequent histo-architectural changes. The experiment involved a 12-month chronic exposure of 28 Wistar female rats at sexual maturity (221 ± g/individual) to lead acetate in drinking water. The rats were divided into 4 groups based on the level of lead exposure: E1 at mg L–1, E2 at mg L–1, E3 at mg L–1 , and a control group that received tap water. Lead level evaluation was performed by atomic absorption spectrometry at nm and the histo-architectonics in target organs were evaluated after hematoxylin and eosin staining and microscopy. The exposure to lead acetate produced significant histological alterations
