The controllers are able to compensate for variation in skin property by adequate tracking of a standard model and the PID controller compensation gain. Modelling and simulations were carried out in MATLAB/SIMULINK and results show a fast response and adequate tracking of the model response irrespective of variations in skin properties. | Journal of Automation and Control Engineering Vol. 4, No. 4, August 2016 Investigation of Hybrid Adaptive Control Schemes for Needle Free Jet Injection System Olaoluwa R. Popoola and Erastus O. Ogunti Federal University of Technology, Akure Ondo state, Nigeria Email: opopson@, oguntig@ Abstract—Voice coils have been used as actuators for needle free jet injection. This voice coils actuators have slow response which could be compensated by PI control but PI control yields a compensated system with static gains, whereas the application in needle free jet injection requires compensation with dynamic gains. This is due to variation in skin properties. This paper implements adaptive control compensation techniques for the design of controllers for voice coil actuators in the needle free jet injection. The controllers are able to compensate for variation in skin property by adequate tracking of a standard model and the PID controller compensation gain. Modelling and simulations were carried out in MATLAB/SIMULINK and results show a fast response and adequate tracking of the model response irrespective of variations in skin properties. Index Terms—voice controllers coils, I. needle free jet [1] developed a model for the interaction between the injection, voice coil and the skin which was a third order transfer function. It is this function that was used in the design of the controller for this research. The requirement of the controller, if drug is to be delivered to different depth in the skin, is that the amount of resultant force is to be varied in proportion with the required depth. This design strategy fails as a minimum force threshold has to be met for the fluid to break to the tough epidermal layer of the skin which consists majorly of the stratum corneum. Hence, a pulse based design strategy time was implemented. This pulse based design maintains constant amplitude for driving the voice coil motor but the frequency of delivery and the .