Ebook 2019 Nelson’s pediatric antimicrobial therapy (25/E): Part 2

(BQ) Part 2 book “2019 Nelson’s pediatric antimicrobial therapy” has contents: Preferred therapy for specific fungal pathogens, preferred therapy for specific viral pathogens, preferred therapy for specific parasitic pathogens, alphabetic listing of antimicrobials, antibiotic therapy for children who are obese, and other contents. | 2019 Nelson’s Pediatric Antimicrobial Therapy — 155 8. Preferred Therapy for Specific Fungal Pathogens NOTES • See Chapter 2 for discussion of the differences between polyenes, azoles, and echinocandins. • Abbreviations: ABLC, amphotericin B lipid complex (Abelcet); AmB, amphotericin B; AmB-D, amphotericin B deoxycholate, the conventional standard AmB (original trade name Fungizone); bid, twice daily; CNS, central nervous system; CSF, cerebrospinal fluid; CT, computed tomography; div, divided; ECMO, extracorporeal membrane oxygenation; HAART, highly active antiretroviral therapy; HIV, human immunodeficiency virus; IV, intravenous; L-AmB, liposomal amphotericin B (AmBisome); PO, orally; qd, once daily; qid, 4 times daily; spp, species; TMP/SMX, trimethoprim/ sulfamethoxazole. Preferred Therapy for Specific Fungal Pathogens 8 155 11/7/18 11:17 AM 8 A. OVERVIEW OF MORE COMMON FUNGAL PATHOGENS AND THEIR USUAL PATTERN OF ANTIFUNGAL SUSCEPTIBILITIES Caspofungin, Micafungin, or Amphotericin B Fungal Species Formulations Fluconazole Itraconazole Voriconazole Posaconazole Isavuconazole Flucytosine Anidulafungin Aspergillus calidoustus ++ — — — — — — ++ Aspergillus fumigatus + — ± ++ + ++ — + Aspergillus terreus — — + ++ + ++ — + Blastomyces dermatitidis ++ + ++ + + + — — 11/7/18 11:17 AM Candida albicans + ++ + + + + + ++ Candida auris ± — ± ± + + ± ++ Candida glabrata + — ± ± ± ± + ± Candida guilliermondii + ± + + + + + ± Candida krusei + — — + + + + ++ Candida lusitaniae — ++ + + + + + + Candida parapsilosis ++ ++ + + + + + + Candida tropicalis + + + + + + + ++ Coccidioides ++ ++ + + ++ + — — 156 — Chapter 8. Preferred Therapy for Specific Fungal Pathogens 156 Preferred Therapy for Specific Fungal Pathogens tropicalis .