.Problem-based Approach and Gastroenterology byJohn N. Plevris MD, PhD, FRCPE, and Reader in for Liver and Digestive Royal Infirmary of , W. Howden MD, FRCP (Glasg.), FACP, AGAF,. of of Gastroenterology and Hepatology,.Northwestern University Feinberg School of John Wiley & Sons, Ltd., edition first published 2012 © 2012 by Blackwell Publishing Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s has been merged with Wiley’s global Scientific, Technical and Medical business to office:John Wiley & Sons, Ltd, The Atrium, Southern Gate, Chichester, West Sussex,.PO19 8SQ, UKEditorial offices:9600 Garsington Road, Oxford, OX4 2DQ, Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, River Street, Hoboken, NJ 07030-5774, USAFor details of our global editorial offices, for customer services and for information about apply for permission to reuse the copyright material in this book please see our website right of the author to be identified as the author of this work has been asserted in the UK Copyright, Designs and Patents Act 1988All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, , in any form or by any means, electronic, mechanical, photocopying, recording , except as permitted by the UK Copyright, Designs and Patents Act 1988, without permission of the publisherDesignations used by companies to distinguish their products are often claimed as trademarks. names and product names used in this book are trade names, service marks, trademarks trademarks of their respective owners. The publisher is not associated with any product mentioned in this book. This publication is designed to provide accurate and in regard to the subject matter covered. It is sold on the understanding that the not engaged in rendering professional services. If professional advice or other expert assistance , the services of a competent professional should be soughtThe contents of this work are intended to further general scientific research, understanding, only and are not intended and should not be relied upon as recommending or promoting method, diagnosis, or treatment by physicians for any particular patient. The publisher author make no representations or warranties with respect to the accuracy or completeness of of this work and specifically disclaim all warranties, including without limitation warranties of fitness for a particular purpose. In view of ongoing research, , changes in governmental regulations, and the constant flow of information relating use of medicines, equipment, and devices, the reader is urged to review and evaluate provided in the package insert or instructions for each medicine, equipment, or , among other things, any changes in the instructions or indication of usage and for and precautions. Readers should consult with a specialist where appropriate. The fact organization or Website is referred to in this work as a citation and/or a potential source information does not mean that the author or the publisher endorses the information or Website may provide or recommendations it may make. Further, readers should that Internet Websites listed in this work may have changed or disappeared between when was written and when it is read. No warranty may be created or extended b