Evaluating the changes of some clinical and subclinical parameters in patients with multiple organ failure supported by continuous renal replacement therapy and comparing some factors related to continuous renal replacement therapy and the outcome of the patients supported by pre- and post-dilution to those by post-dilution only. | Journal of military pharmaco-medicine no7-2018 EVALUATE THE CHANGE OF SOME PARAMETERS IN PATIENTS WITH MULTIPLE ORGAN FAILURE SUPPORTED BY CONTINUOUS RENAL REPLACEMENT THERAPY Huynh Thi Ngoc Thuy*; Hoang Trung Vinh**; Do Quoc Huy* SUMMARY Objectives: Evaluating the changes of some clinical and subclinical parameters in patients with multiple organ failure supported by continuous renal replacement therapy and comparing some factors related to continuous renal replacement therapy and the outcome of the patients supported by pre- and post-dilution to those by post-dilution only. Subjects and methods: Prospective trial, compare before and after intervention in 77 patients diagnosed as multiple organ failure according to SOFA score. The patients were divided into 2 groups: 41 patients in group 1 - study group (supported by pre- and post-dilution), 36 patients in group 2 - control group (supported by post-dilution). Data were received from clinical examination, diagnostic tests during treatment. Results: Comparing with post-dilution, patients in group of pre- and postdilution had significant TNF-α clearance (p 18 years diagnosed with MOF according to the SOFA score (table 1). + 6 organs: Cardiovascular, respiratory, kidney, liver, coagulation, central nervous system. + Criteria: SOFA score ≥ 2 or defined by one of three approaches: . As a single variable that reflects a physiologic derangement. . As a single variable that reflects a therapeutic intervention in response to a physiologic derangement. . As a combination of variables that in their own right define a syndrome. + Acute liver failure (ALF) with 1 in 2 following criteria: total bilirubin level > mg/dL or having all of 3 criteria of ALF by the AASLD (table 3). + MOF: At least 2 failured organ and lasting more than 24 hours. - Have the acute kidney injury identified by RIFLE criteria (table 2): Serum creatinine increased 2 times compared to baseline, urine output 50 mL/h, serum creatinine 5 or epinephrin ≤ .
