To investigate the relationship between 9 serum cytokines and clinical, subclinical characteristics in patients with new AFB negative pulmonary tuberculosis. 88 patients with AFB-negative pulmonary tuberculosis were treated at Department of Tuberculosis and Lungs Diseases, 198 Hospital. | Journal of military pharmaco-medicine no7-2018 RESULTS OF 9 SERUM CYTOKINES IN PATIENTS WITH NEW AFB NEGATIVE PUMONARY TUBERCULOSIS Dinh Thi Hoa*; Tran Van Sau*; Nguyen Huy Luc** SUMMARY Objectives: To investigate the relationship between 9 serum cytokines and clinical, subclinical characteristics in patients with new AFB negative pulmonary tuberculosis. Subjects and methods: 88 patients with AFB-negative pulmonary tuberculosis were treated at Department of Tuberculosis and Lungs Diseases, 198 Hospital. We performed nine simultaneous cytokines tests (including IL-2, IL-4, IL-5, IL-10, IL-12, IL-13, GM-CSF, IFN gamma, TNF alpha) at Immuno Labo-Center for Medicine and Pharmacy, Military Medical University. Results: Mean concentrations of cytokines: IL-4: ; IL-5: ± ; IL-10: ± ; IL-12: ± 292 47; IL-13: ± ; TNF: ± , alpha TNF: ± . The group of weight loss patients had a decreased cytokine value compared with the unweight group, with a difference of p ). Table 6: Relations between serum cytokine levels and peripheral white blood cell characteristics of the two groups. Cytokine White blood cells normal (n = 73) White blood cells increase (n = 15) p IL-2 ± ± IL-4 ± ± IL-5 ± ± IL-10 ± ± IL-12 ± ± IL-13 ± ± IFN gamma ± ± TNF alpha ± ± CSF ± ± The table above shows that cytokine concentrations were not associated with elevated white blood cell counts (p > ). DISCUSSION 1. Average concentration of serum cytokines. For years, authors in many countries around the world have focused on the issue of immunity in TB. In terms of the 142 occurrence of cytokines, and the increase in the concentration in each .
