Primary lung cancer is one of the most common malignant diseases. The expression of Ciz1b appears to be limited to tumor cells, suggesting that this variant can be used as a marker for the cancer. This study is to evaluate the expression and diagnostic role of Ciz1b in lung cancer patients. | Journal of military pharmaco-medicine n08-2018 EXPRESSION OF Ciz1b IN PATIENTS WITH NON-SMALL CELL LUNG CANCER Ho Van Son1,2; Ngo Tat Trung1,3; Nguyen Linh Toan1 SUMMARY Introduction: Primary lung cancer is one of the most common malignant diseases. The expression of Ciz1b appears to be limited to tumor cells, suggesting that this variant can be used as a marker for the cancer. This study is to evaluate the expression and diagnostic role of Ciz1b in lung cancer patients. Subjects and methods: 100 patients with non-small cell lung cancer and 51 healthy controls were recruited for this study. Relative expression of Ciz1b mRNA was determined by realtime PCR. Results: Increased Ci1zb mRNA expression was observed in patients with non-small cell lung cancer compared to healthy individuals (p = ). The expression of Ciz1b mRNA was negatively correlated with the ALT enzyme levels (Spearman's r = , p = ) and with the AST levels (Spearman' r = , p = ). The level of mRNA expression of the Ci1zb gene was significantly associated with tumor cell differentiation in patients with non-small cell lung cancer. Ciz1b mRNA expression in serum was capable of distinguishing lung cancer patients from healthy control (AUC = , p = ). Conclusion: The expression of Ciz1b is regulated by the occurrence of lung cancer and Ci1zb plays an important role in lung cancer development, as well as has the potential as a biomarker for diagnosis and prognosis of lung cancer. * Keywords: Lung cancer; Non-small-cell lung carcinoma; Ciz1b; mRNA expression. INTRODUCTION Primary lung cancer is one of the most common malignant diseases and also is one of the leading causes of death from cancers. Lung cancer accounts for about 12% of all types of cancers and 18% of cancer-related deaths [1, 2]. Of these, non-small-cell lung carcinoma (NSCLC) accounts for more than 80% of lung cancer. In Vietnam, lung cancer has increased rapidly due to smoking, air pollution, dust emissions .
