Glioblastoma is the most prevalence primary malignant brain tumor, which takes up 16% of all primary brain and central nervous system malignancy. Molecular variations or gene expression patterns have also been recognized in primary and secondary glioblastomas. Genetic typical alterations for primary glioblastoma are epidermal growth factor receptor and fibroblast growth factor receptors variations. | Journal of military pharmaco-medicine no1-2019 MUTATION ANALYSIS OF EGFR AND FGFR GENE IN GLIOBLASTOMA PATIENTS IN VIETNAM Kieu Dinh Hung1; Nguyen Thi Thom1; Tran Quoc Dat1; Dang Thi Ngoc Dung1 Tran Huy Thinh1; Tran Van Khanh1; Ta Thanh Van1 SUMMARY Background: Glioblastoma is the most prevalence primary malignant brain tumor, which takes up 16% of all primary brain and central nervous system malignancy. Molecular variations or gene expression patterns have also been recognized in primary and secondary glioblastomas. Genetic typical alterations for primary glioblastoma are epidermal growth factor receptor and fibroblast growth factor receptors variations. Subjects and methods: We recruited 60 patients diagnosed with primary glioblastoma in which biopsy samples were collected to assess for FGFR and EGFR mutations. Results and conclusion: 6/60 patients () were positive with FGFR mutation (, , ). 8/60 patients () were identified with EGFR, a total of 7 mutations were identified , , , , , , . This is the first study on FGFR and EGFR mutation in glioblastoma patients in Vietnam. The results would contribute to better understanding the pathological and molecular mechanism of glioblastoma in Vietnam. * Keywords: Glioblastoma; EGFR; FGFR; Mutation analysis. INTRODUCTION Glioblastoma (GBM) is the most prevalence primary malignant brain tumor, which take up 16% of all primary brain and central nervous system malignancy [1]. The average age-adjusted incidence rate in the population is per 100,000 [1]. GBMs were primary thought to be resulting exclusively from glial cells; however, recent studies suggest that they may result from several cell types with neural stem cell-like properties [2]. By the end of the genomic profiling and the Cancer Genome Atlas project (Parsons et al 2008), more than 600 genes were profiled from more than 200 human tumor samples, which revealed the complex genetic .
