Objectives: To study formulation of sub-coating of lansoprazole (LPZ) loading core pellets. Methods: The drug loading core pellets and sub-coating pellets were coated by using fluidized bed coater. Spectrophotometric method was used to determine the drug content and percentage of drug release from pellets. | Journal of military pharmaco-medicine no4-2018 STUDY ON FORMULATION OF SUB-COATING OF LANSOPRAZOLE LOADING CORE PELLETS Luong Quang Anh*; Nguyen Ngoc Chien*; Nguyen Dang Hoa** SUMMARY Objectives: To study formulation of sub-coating of lansoprazole (LPZ) loading core pellets. Methods: The drug loading core pellets and sub-coating pellets were coated by using fluidized bed coater. Spectrophotometric method was used to determine the drug content and percentage of drug release from pellets. The influences of polyethylene glycol 6000, lutrol F127, talcum and solid content on the productivity of pellets, dissolution of LPZ from drug loading core pellets in phosphate buffer of pH were evaluated. Results: Formulation of sub-coating of LPZ loading core pellets was established containing polyvinyl alcohol (5%), polyethylen glycol 6000 (), lutrol F127 (1%), titan dioxide (2%), talcum (2%). Weight of solid ingredients at was chosen. LPZ loading core pellets were sub-coated with polyvinyl alcohol up to weight gain. The sub-coating membrane was created to protect LPZ loading core pellets from acidic environment, and to avoid the interaction between the membrane and enteric coating. Conclusion: The sub-coating for LPZ loading core pellets was performed successfully in laboratory. * Keywords: Lansoprazole; Pellet; Sub-coating. INTRODUCTION Lansoprazole reduces gastric acidity, an important factor in healing acid-related disorders such as gastric ulcers, duodenal ulcers, and reflux oesophagitis. LPZ was used to treat gastro-oesophageal reflux, ulcers, acid-related dyspepsia, etc [2, 9]. The drug belongs to proton pump inhibitor group. In previous research, LPZ was loaded onto inert core pellets to form a drug layer using fluidized bed coater. In fact, it is necessary to formulate an enteric coating for pellets containing LPZ due to the degradation of the active pharmaceutical ingredient as LPZ in acidic medium [3, 6]. However, the acidity of enteric coating .
